On May 1st, Beijing time, Ishikawa Kasumi, a famous Japanese table tennis player, posted on social media and officially announced his retirement.

　　"I have decided to retire after the WTT Macau Championship in April. I hope that I can concentrate and go all out in the last game of active service, just like every other game. I am really sorry that I failed to announce my retirement in advance before the game. "

　　"After entering 2023, I feel that every game may be the last game of my table tennis career. I have been carrying this idea and have gone all out to face and enjoy every game. Now, I feel that I have been very satisfied with my table tennis career and have done my best, so I made a decision to retire calmly. "

　　Ishikawa Kasumi

　　"I started to learn to play at the age of 7, and my 23-year ping-pong career has brought me the most valuable experience in my life. Since the London Olympics, I have won medals in three consecutive Olympic Games, won the world championship in mixed doubles, and won five championships in all-Japan championships. In my career, there are many games worth remembering. "

　　"Since I was 14 years old, I have participated in various international competitions as a member of the Japanese national team. For a long time, I have been able to compete at the top level in the world, and many dreams have come true, which makes me very happy and happy."

　　Ishikawa Kasumi also talked about her relationship with China table tennis in her retirement article and expressed her gratitude.

　　"Since middle school, I have been training with coach China at every stage. Along the way, I have met many coaches who have helped me, which is very precious to me. I have also started to contact and absorb China culture and Chinese a little bit. Because I know Chinese, I can communicate with friends and fans in China. I am really happy."

　　"Every time I compete in China, I can feel your enthusiasm. Thank you for the strength and warmth you have always brought me!"

　　"No matter when I am happy to win, or when I am depressed after the game, you will accompany me all the time. I hope that the fans who have watched me play will have a positive attitude in the face of every day in the future, which will make me happy. "

　　Ishikawa Kasumi also looked forward to the future in the article: "From now on, although everything is a new beginning, I will never forget the attitude that the ping-pong spirit has brought me challenges. I will face various challenges and look forward to it. I really appreciate your support all the time!"

　　It is reported that Ishikawa Kasumi’s retirement press conference will be held on May 18th, at which she will share her mental journey with the fans in more detail.

1. Breaststroke-freestyle-backstroke-butterfly

2. freestyle-breaststroke-backstroke-butterfly

Among them: freestyle is the fastest. Breaststroke is best for exercise. In particular, it can shape beautiful leg and waist curves. The butterfly stroke is the most beautiful, like a mermaid. Backstroke is the most energy-saving and suitable for self-help. Hand-stroke to the back and "down" side. Palm down when paddling. Strive for maximum buoyancy and driving force. When the water comes out, the hand is in the shape of a "knife" (that is, the palm of the hand is opposite to the heart of the hand) to minimize the resistance. Legs-kick down and back. When retracted, the thighs and knees are open and the feet jump. (Think of frogs) Coordination-pushing water by hand and pedaling water alternately. Breathing-learning breaststroke, breathing is more difficult to master. Have to experience it several times. When the hand pushes the water downward, the body will float upwards. Take the time to let the head surface and take a breath. Beginners first learn hand posture in shoulder-deep water (the water is too shallow to feel). Lean forward when practicing. Learn to let your hands control the balance of your body. When you find the feeling, pedal your feet gently. You can try to float. At this time, you can try to cooperate with your hands and feet.

Frequently asked questions and answers:
1. Why do I always swim sideways in freestyle? It was straight, but after swimming for a while, it turned 90 degrees!
A: The posture is wrong and the force is not balanced. First, keep in mind that the goal is ahead. Second, when the hand enters the water, it should be in front of the chest, rowed to the chest, and then accelerated backwards to the side of the body to get out of the water. Seen from the side as an S-shaped curve. Third, the force should be balanced when the feet alternately pat down the water and push back the water. Fourth, when the head is swinging sideways to breathe, the direction of the hand entering the water should be kept in a straight line with the body. I think your hand may have changed direction when you swung your head, so you turned.

2, which brother gives a breathing skill? I always choke on water! ! !
A: The most difficult thing for beginners to master breaststroke is breathing.
Breathe out in the "O" shape in the water for three seconds. When your legs are holding water and your feet are close together, your hands should "press" the water to your chest. With these two forces, your head can naturally be lifted out of the water. Take a breath with your mouth immediately, for about a second. Remember, breaststroke breathes with your mouth, not your nose, so as not to choke water. ) at first, you may only be able to lift your head once or twice, and you are hardly in a hurry. But the posture is right, practice a few times more, and naturally you can cooperate with your hands and feet and breathe freely.

3. I am learning to swim recently, but why do I always turn around in the same place and find it difficult to move forward?
A: Moving forward mainly depends on the downward and backward pushing force of the feet. I think your legs only have the power to beat the water down, but not the power to push the water, so you can only move in place.

4. Do you use your hands and feet when swimming? Why can’t the body float?
A: The above two pictures show the hand-foot coordination posture of freestyle and breaststroke. Freestyle: Breathing, paddling and kicking 1: 2: 2 or 1: 2: 4. The second picture shows the breaststroke posture. From the picture, we can see that the human body is changing in a curved way. When swimming, when your feet are open, your hands are put together in a knife shape and stretched forward. At this time, your feet are hard and your hands are labor-saving. When the feet catch water backwards and recover it, the hands are separated to paddle downwards and backwards. At this time, the main force is the hand. So when you swim, you basically feel that your hands and feet alternate, not at the same time. Many beginners swim with their hands open and their feet open, and then their hands and feet are close together at the same time, which is wrong. It should be done alternately.
5. Is there any trick to holding your breath? It seems very uncomfortable to hold it for a long time.
Answer: When holding your breath, don’t inhale too much oxygen, which is about three-quarters of the maximum inspiratory capacity, and then breathe out when you can’t hold it any longer. When you breathe out, you breathe out a little, then hold it for a while, and then spit again. If you repeat this, you can hold it for a little longer.

A little advice:
Without a good teacher, it is very difficult to learn to fool around in the water alone. Therefore, it is very important to hire a good coach and master the methods.

How to learn to swim the fastest? What’s your experience?
Action structure and technical points
(1) The swimmer is in gliding posture, and his body is close to horizontal. About 80% of the head is submerged in the water, the face is slightly forward, the arms are extended, and the palm is facing the oblique outer side (2). The water catching action begins at about 7~9 inches underwater, and the hands are paddling sideways, and then the exhalation action begins.
(3) The arms have no obvious flexion, and they continue to row to the outside, and the exhalation continues to increase.
(4) When the swimmer’s head starts to move slightly upwards, the elbow joint starts to flex and the upper arm starts to rotate.
(5) When the arms reach the maximum width and the elbows bend about 110 degrees, the high elbow posture is obvious.
(6) Keep the head up, and when the mouth is out of the water, finally exhale. Hands begin to move inward to complete the final propulsion.
(7) When your arms are ready to go backwards, start inhaling, and don’t pull your elbows under the ribs. The knee joint begins to flex and the leg return movement begins.
(8) The mouth is closed, the inhalation is completed, the feet are brought to the buttocks, the elbow joint continues to extend, and the arms continue to move forward.
(9) Leg-returning action continues.
(10) The neck flexes and the head continues to tilt downward. Feet dorsiflexion, legs begin to move backwards, water pushing action, arms returning action.
(11) Push your feet back and start to come together. The swimmer then holds his breath until another stroke begins.
(12) Arms fully extended, hands slightly below the shoulder level, and legs kicking water nearly completed. When the swimmer completes the kick, he concentrates on keeping his body in a straight line. He will keep this gliding posture for a short time, and then when he feels the speed slow down, another arm stroke cycle begins.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

　　　　　 First, drive an elevated road along Humin Road. 6 kilometers from exit to enter Shanghai to Kunming highway

　　Second, in Shanghai to Kunming Highway

　　1) Drive 430 meters along the Shanghai -Kunming Expressway. Hangzhou/G60/Ningbo/Xinzhuang direction, open a small right

　　2) Continue along Shanghai to Kunming Expressway 27. 6 kilometers straight into the Hangzhou Bay Ring Road Expressway

　　Third, Hangzhou Bay Wound Highway Expressway

　　Travel 52 along Hangzhou Bay Ring Road. 7 kilometers, go directly to Hangzhou, open a little bit of Shanghai to Kunming highway

　　Fourth, in Shanghai to Kunming Expressway.

　　Travel along Shanghai to Kunming highway. 3 kilometers, go directly to Hangzhou/ Qiandao Lake/ S2, and turn to Hangzhou -Ningbo Expressway

　　Fifth, Hangzhou -Ningu Highway

　　1) Drive along Hanging Highway 21. 9 kilometers directly to Hangzhou/Desheng Road, and it becomes a little bit of Disheng

　　2) Walk 610 meters along Desheng Road, and open a small right

　　Sixth, Zhejiang driving plan

　　1) Continue to run 840 meters along De Sheng, enter Disheng Fast from the entrance

　　2) Drive 680 meters along Desheng quickly, leave the slope from the airport exit

　　3) Drive 360 ??meters along the ramp and go straight into Dusheng East Road

　　4) 580 -meter driver along the Sheng Dong Road, turn left in front to enter the airport road

　　5) 3 drivers along the airport road. 7 kilometers, in the direction of the Chengdong Bridge Stadium, rotate the bridge slightly

　　6) Travel along the bridge 1. About 60 meters after 2 kilometers from the Hangzhou Criminal Investigation Building, go straight into the field

　　7) 2 drivers along the stadium road. Turn left to the ancient Xinhe Bridge at 9 kilometers and enter Western Road

　　8) 530 meters along the West Road of the Ring City, open the provincial roads and bridges into the provincial government

　　9) Drive 280 meters along the provincial government. Arrive at the end (on the right side of the road)

Mobile phone access　Shanghai local treasure first page

New youth

Always accompany you all the way

At 3:40 pm on November 29, the women’s basketball competition was held in the large playground, and the School of Mechanical and Electrical Engineering VS Materials and Environmental Engineering College.

At the beginning of the game, the basketball athletes of the Mechanical and Electrical Institute took the initiative to pass the ball with a good and skilled movement, and to force the rebound. Our team members quickly entered the state, and they were all heroic. On the court, you are fighting for me, you attacked me, and you have a skilled pitching. The pitching movements are handsome and neat. At the same time, the cheerleaders also shouted outside the court, and the atmosphere of the court was very active. In the end, the School of Mechanical and Electrical Engineering won the game at 25:19.

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After this basketball game, it not only enriched the students ‘extra -curricular life, but also strengthened the students’ awareness of exercising and solidarity and cooperation, allowing students to relax their body and mind in the intense study life, and felt the strength and warmth of the group’s groups. Essence I hope that our women’s basketball team members will be overwhelmed all the way in the next game and break the waves to win a better ranking!

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